嗅觉回避试验（小鼠）

Background

Olfactory system is a good model for studying the sensory processing in the brain. To characterize innate fear responses such as freezing and avoidance in genetically modified mice, the olfactory avoidance test was performed using a component of fox feces, TMT (2,5-dihydro-2,4,5-trimethylthiazoline; Kobayakawa et al., 2007). Furthermore, the olfactory avoidance using the different amounts of TMT was carried out to know the odor detection threshold in gene-knockout mice (Kaneko-Goto et al., 2013). Recently, we have reported that non-dihydrogenated TMT (nTMT: 2,4,5-trimethylthiazole) also induces similar freezing and avoidance responses (Takahashi et al., 2016). Here, we describe a method for the olfactory avoidance test with nTMT (commercially available) to explore the odor detection threshold in mice. This method has an advantage in the point using a simple device such as cage and filter paper, compare with that using an olfactometer.

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