SD大鼠

起源1925年Robert W.Dawley将一只杂种雄性和一只雌性Wistar大鼠交配，得到该品系。

特征与用途

◇解剖：头部狭长，尾长接近于体长，产仔多，生长发育较Wistar快。

◇免疫：抗病能力强，尤其对呼吸道疾病的抵抗力强。

◇肿瘤：自发肿瘤发生率低。

◇生理：对性激素敏感性高。

◇用途：常用作营养学，内分泌学和毒理学等方面的研究。

饲料大小鼠繁殖料

来源于查氏瑞华大鼠的生长曲线：

来源于Taconic大鼠的生长曲线和生理指标：

Average litter size:10

SD Physiological Data Summary (April 2004; N=10/group):

ParameterUnitsSprague

Dawley® MalesSprague

Dawley® Females

Serum Chemistry

Avg ± S.D.

Calcium

mg/dL

12.3 ± 0.4

11.4 ± 3.5

Phosphorous

mg/dL

12.6 ± 1.1

12.4 ± 1.4

Glucose

mg/dL

82.4 ± 11.3

93.2 ± 10.3

Creatinine

mg/dL

0.3 ± 0.1

0.3 ± 0.1

BUN

mg/dL

9.1 ± 1.4

13.6 ± 3.0

Total Bilirubin

mg/dL

0.1 ± 0.0

0.1 ± 0.0

ALK

U/L

227.7 ± 36.1

142.5 ± 33.9

ALT U/L

U/L

29.3 ± 3.4

22.5 ± 3.9

Total Protein

g/dL

6.4 ± 0.2

6.7 ± 0.2

Blood Counts

Erythron

Red Blood Cells

X106/uL

6.9 ± 0.3

7.7 ± 0.3

Nucleated RBC

X106/uL

0

0

Hemoglobin

g/dL

14.5 ± 0.8

16.1 ± 0.6

Hematocrit

%

48.3 ± 2.3

51.2 ± 2.6

MCV

fL

69.9 ± 1.7

66.9 ± 0.9

MCH

pG

20.9 ± 1.3

21.0 ± 1.1

MCHC

%

29.9 ± 1.6

31.4 ± 1.9

Platelets

Platelets

X103/uL

1358.0 ± 123.8

1262.2 ± 278.4

Leukogram

White Blood Cells

x103/uL

9.4 ± 3.2

6.0 ± 1.5

Neutrophil

x103/uL

0.9 ± 0.5

0.4 ± 0.3

Bands

x103/uL

0

0

Lymphocyte

x103/uL

8.3 ± 2.9

5.5 ± 1.4

Monocytes

x103/uL

0.3 ± 0.3

0.1 ± 0.1

Eosinophil

x103/uL

0

0

Basophils

x103/uL

0

0

Others

x103/uL

0

0

Organ Weights

Stomach

g

2.02 ± 0.12

1.54 ± 0.17

Ileum

g

6.19 ± 0.62

4.83 ± 0.35

Colon

g

0.77 ± 0.37

0.85 ± 0.21

Lungs

g

1.69 ± 0.14

1.31 ± 0.19

Heart

g

1.24 ± 0.14

0.90 ± 0.10

Liver

g

11.37 ± 1.12

7.17 ± 0.62

Spleen/Pancreas

g

1.58 ± 0.15

1.17 ± 0.23

Kidney (L)

g

1.08 ± 0.1

0.82 ± 0.08

Kidney (R)

g

1.09 ± 0.09

0.85 ± 0.08

Testes (L)

g

1.33 ± 0.17

-

Testes (R)

g

1.33 ± 0.14

-

Ovary (L)

g

-

0.08 ± 0.01

Ovary (R)

g

-

0.08 ± 0.01

Urinalysis

Glucose

mg/dL

Negative

Negative

Blood

-

Negative

Negative

pH

-

6.75 ± 0.35

6.7 ± 0.4

Protein

mg/dL

N/A

N/A

Specific Gravity

-

1.0195 ± 0.0068

1.0155 ± 0.0079

One Year Growth Chart

Taconic Sprague Dawley® Rats Average Control Group Body Weight in Grams

One Year Toxicology Study (N=20)

Weeks of Age678910

Female

152.71

184.13

209.71

227.55

241.11

Male

163.01

225.98

276.15

306.93

336.53

Weeks of Age1112131415

Female

256.33

260.37

271.94

279.08

291.5

Male

361.71

378.11

396.8

412.86

431.21

Weeks of Age1617182226

Female

295.22

298.41

303.42

315.48

335.41

Male

441.56

454.14

461.01

491.98

514.05

Weeks of Age3034384246

Female

350.74

357.83

368.19

383.44

392.05

Male

528.94

544.33

556.88

568.96

568.41

Weeks of Age505458

Female

408.44

421.01

426.79

Male

579.1

584.42

577.79

来源于Charles River大鼠的生长曲线和生理指标：

CDIGSRatModelInformationSheet.pdf

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